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Clinical Research Trials Available

The following Clinical Research Trials are available through Mercy.   Additional information can be found at www.clinicaltrials.gov.

 

Infectious Disease 419-251-4919

Clostridium difficille infection (C-Diff) Protocol Clincaltrials.gov link
  A multi-center, randomized, double-blind study to compare the efficacy and safety of cadazolid versus vancomycin in subjects with Clostridium difficile associated diarrhea http://www.clinicaltrials.gov/ct2/show/NCT01983683?term=NCT+01983683&rank=1
Sepsis Protocol Clincaltrials.gov link
  A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study to Assess the Safety and Efficacy of ART-123 in Subjects with Severe Sepsis and Coagulopathy http://www.clinicaltrials.gov/ct2/show/NCT01598831?term=NCT+01598831&rank=1
Bacterial Skin Infections Protocol Clincaltrials.gov link
  A Phase 3b, Double-Blind, Multicenter, Randomized Study to Compare the Efficacy and Safety of single Dose Dalbavancin to a Two Dose Regimen of Dalbavancin for the Treatment of Acute Bacterial Skin and Skin Structure Infections http://www.clinicaltrials.gov/ct2/show/NCT02127970?term=Dalbavancin&rank=1
  A Phase 3, multicenter, randomized, double-blind, active-controlled study to evaluate the efficacy and safety of IV and oral delafloxacin compared with vancomycin + aztreonam in patients with acute bacterial skin and skin structure infections.  

PULMONARY 419-251-4919

COPD Protocol Clincaltrials.gov link
  A Double-blind, Randomized, Placebo-controlled, Parallel-group, Phase IV study to evaluate the effect of Aclidinium Bromide on long-term Cardiovascular safety and COPD exacerbations in Patients With Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD). Phase 4-Tudorza        http://www.clinicaltrials.gov/ct2/show/NCT01966107?term=NCT+01966107&rank=1
  A randomized, double-blind, active-controlled parallel group study to evaluate the effect of 52 weeks of once daily treatment of orally inhaled tiotropium + olodaterol fixed dose combination compared with tiotropium on Chronic Obstructive Pulmonary Disease (COPD) exacerbation in patients with severe to very severe COPD. [DYNAGITO I]  

SLEEP 419-251-4919

Narcolepsy Protocol Clincaltrials.gov link
Pediatric A Randomized, Open-Label Study to Characterize the Pharmacokinetics, Pharmacodynamics, and Safety of Single and Multiple Doses of armodafinil (50, 100 and 150 mg per day) in Children and Adolescents with Excessive Sleepiness Associated with Narcolepsy http://www.clinicaltrials.gov/ct2/show/NCT01624480?term=NCT+01624480&rank=1
     

CARDIAC 419-251-4919

Atrial Fibrilation Protocol Clincaltrials.gov link
  GLORIA - AF: Global Registry on Long-Term Oral Anti-thrombotic TReatment In PAtients with Atrial Fibrillation (Phase II/III) http://www.clinicaltrials.gov/ct2/show/NCT01468701?term=NCT01468701&rank=1 
Cardiac Intervention Protocol Clincaltrials.gov link
Leads Product Surveillance Registry http://www.clinicaltrials.gov/ct2/show/NCT01524276?term=NCT01524276&rank=1
STENT BIOTRONIK - A Prospective Randomized Multicenter Study to Assess the Safety and Effectiveness of the Orsiro Sirolimus Eluting Coronary Stent System in the Treatment Og Subjects With up to Three De Novo or Restenotic Coronary Artery Lesions - V  
Randomized Controlled Trial Clinical Evaluation of the ABSORB™ Bioresorbable Vascular Scaffold (BVS) in the Treatment of Subjects with de novo Native Coronary Artery Lesions http://www.clinicaltrials.gov/ct2/show/NCT01751906?term=NCT+01751906&rank=1

Oncology 419-251-4919

Lung Protocol Clincaltrials.gov link
Non-Squamous, non-small cell A Phase III open label randomized study of MPDL3280A (Anti-PD-L1 Antibody) in combination with carboplatin + paclitaxel with or without bevacizumab compared with carboplatin + paclitaxel + bevacizumab in chemotherapy naïve patients with stage IV non squamous non-small cell lung cancer https://www.clinicaltrials.gov/ct2/show/NCT02366143?term=NCT02366143&rank=1
Hematology Protocol Clincaltrials.gov link
Multiple Myeloma A Phase 3, Randomized, Double-Blind, Multicenter Study Comparing Oral MLN9708 Plus Lenalidomide and Dexamethasone Versus Placebo Plus Lenalidomide and Dexamethasone in Adult Patients With Newly Diagnosed Multiple Myeloma http://www.clinicaltrials.gov/ct2/show/NCT01850524?term=NCT01850524&rank=1
Advanced B-Cell An open label,Phase 1/2 study of MEDI-551, A Humanized Monoclonal Antibody Directed against CD19, in adult subjects with relapsed or refractory advanced B-cell Malignancies http://www.clinicaltrials.gov/ct2/show/NCT00983619?term=NCT+00983619&rank=1
Pancreatic Protocol Clincaltrials.gov link
Advanced or metastatic Adenocarcinoma of the Pancreas A randomized,double blind phase 3 study of the JAK1/2 inhibitor, ruxolitinib or placebo in combination with Capecitabine in subjects with advanced or metastatic adenocarinoma of the pancreas who have failed or are intolerant to first line chemotherapy http://www.clinicaltrials.gov/ct2/show/NCT02117479?term=NCT+02117479&rank=1 
Other Protocol Clincaltrials.gov link
Polycythemia Vera Prospective non intervential study of disease progression and treatment of patients with polycythemia vera in United States academic or community clinical practices  (REVEAL) http://clinicaltrials.gov/ct2/show/NCT02252159?term=02252159&rank=1 
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