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Clinical Research Trials Available

The following Clinical Research Trials are available through Mercy.   Additional information can be found at www.clinicaltrials.gov.

Infectious Disease 419-251-4919
Clostridium difficille infection (C-Diff)ProtocolClincaltrials.gov link
 A Phase III, Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy, Safety and Tolerability of a Single Infusion of MK-6072 (Human Monoclonal Antibody to Clostridium difficile toxin B) and MK-3415A (Human Monoclonal Antibodies to Clostridium difficile toxin A and toxin B) in Patients Receiving Antibiotic Therapy for Clostridium difficile Infection (MODIFY II)http://www.clinicaltrials.gov/ct2/show/NCT01513239?term=NCT+01513239&rank=1
 A Randomized, Double-Blinded, Active-Controlled Study of CB-183,315 in Patients with Clostridium Difficile Associated Diarrheahttp://www.clinicaltrials.gov/ct2/show/NCT01597505?term=NCT+01597505&rank=1
 A multi-center, randomized, double-blind study to compare the efficacy and safety of cadazolid versus vancomycin in subjects with Clostridium difficile associated diarrheahttp://www.clinicaltrials.gov/ct2/show/NCT01983683?term=NCT+01983683&rank=1
InfluenzaProtocolClincaltrials.gov link
  A Phase III International, Randomized, Double-Blind, Double-Dummy Study to Evaluate The Efficacy and Safety of 300 mg or 600 mg of Intravenous Zanamivir twice Daily compared to 75 mg or oral oseltamivir Twice Daily in the Treatment of Hospitalized Adults and Adolescents with Influenzahttp://www.clinicaltrials.gov/ct2/show/NCT01231620?term=NCT+01231620&rank=1
SepsisProtocolClincaltrials.gov link
 A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study to Assess the Safety and Efficacy of ART-123 in Subjects with Severe Sepsis and Coagulopathyhttp://www.clinicaltrials.gov/ct2/show/NCT01598831?term=NCT+01598831&rank=1
Bacterial Skin InfectionsProtocolClincaltrials.gov link
 A Phase 3b, Double-Blind, Multicenter, Randomized Study to Compare the Efficacy and Safety of single Dose Dalbavancin to a Two Dose Regimen of Dalbavancin for the Treatment of Acute Bacterial Skin and Skin Structure Infectionshttp://www.clinicaltrials.gov/ct2/show/NCT02127970?term=Dalbavancin&rank=1
   
PULMONARY 419-251-4919
COPDProtocolClincaltrials.gov link
 A Double-blind, Randomized, Placebo-controlled, Parallel-group, Phase IV study to evaluate the effect of Aclidinium Bromide on long-term Cardiovascular safety and COPD exacerbations in Patients With Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD). Phase 4-Tudorza           http://www.clinicaltrials.gov/ct2/show/NCT01966107?term=NCT+01966107&rank=1
 Randomised, double-blind, placebo- and active-controlled parallel group study to assess the efficacy and safety of 12 weeks of once daily treatment of two doses of orally inhaled tiotropium + olodaterol fixed dose combination (delivered by the Respimat® inhaler) in patients with moderate to severe COPD.(FEV1< 80%)http://www.clinicaltrials.gov/ct2/show/NCT01964352?term=NCT+01964352&rank=1
IPFProtocolClincaltrials.gov link
 A double blind randomized placebo controlled trial evaluating the effect of oral nintedanib 150 mg twice daily on high resolution computerized tomography quantitative lung fibrosis score, lung function, six minute walk test distance and St. George’s Respiratory Questionnaire after twelve months of treatment in patients with Idiopathic Pulmonary Fibrosis with continued evaluations over a period of up to eighteen monthshttp://www.clinicaltrials.gov/ct2/show/NCT01979952?term=NCT+01979952&rank=1
   
SLEEP 419-251-4919
NarcolepsyProtocolClincaltrials.gov link
PediatricA Randomized, Open-Label Study to Characterize the Pharmacokinetics, Pharmacodynamics, and Safety of Single and Multiple Doses of armodafinil (50, 100 and 150 mg per day) in Children and Adolescents with Excessive Sleepiness Associated with Narcolepsyhttp://www.clinicaltrials.gov/ct2/show/NCT01624480?term=NCT+01624480&rank=1
   
CARDIAC 419-251-4919
Atrial FibrilationProtocolClincaltrials.gov link
 GLORIA - AF: Global Registry on Long-Term Oral Anti-thrombotic TReatment In PAtients with Atrial Fibrillation (Phase II/III)http://www.clinicaltrials.gov/ct2/show/NCT01468701?term=NCT01468701&rank=1 
Cardiac Disease and ArthritisProtocolClincaltrials.gov link
 Prospective Randomized Evaluation of Celecoxib Integrated Safety vs. Ibuprofen Or Naproxen- A Randomized, Double Blind, Parallel-Group Study of Cardiovascular Safety In Osteoarthritis or Rheumatoid Arthritis Patients With or at High Risk for Cardiovascular Disease Comparing Celecoxib With Naproxen and Ibuprofenhttp://www.clinicaltrials.gov/ct2/show/NCT00346216?term=NCT00346216&rank=1
Cardiac InterventionProtocolClincaltrials.gov link
 Product Surveillance Registryhttp://www.clinicaltrials.gov/ct2/show/NCT01524276?term=NCT01524276&rank=1
On Hold Phase 3 study to determine the efficacy of REG1 compared to bivalirudin in preventing periprocedural ischemic complications and major bleeding in patients undergoing PCI in both ACS (NSTEMI and unstable angina [UA] and elective PCIhttp://www.clinicaltrials.gov/ct2/show/NCT01524276?term=NCT01524276&rank=1
   
Oncology 419-251-4919
GUProtocolClincaltrials.gov link
RenalAn International Phase 3 Randomized Trial of Autologous Dendritic Cell Immunotherapy (AGS-003) Plus Standard Treatment of Advanced Renal Cell Carcinoma.http://www.clinicaltrials.gov/ct2/show/NCT01582672?term=NCT01582672&rank=1
HematologyProtocolClincaltrials.gov link
T-Cell Lymphoma A Phase 3, Randomized, Two-Arm, Open-Label, Multicenter Trial of Allsertib (MLN8237) or Investigators Choice (Selected Single Agent) in Patients with Relapsed or Refractory Peripheral T-cell Lymphoma http://www.clinicaltrials.gov/ct2/show/NCT01482962?term=NCT+01482962&rank=1
Multiple MyelomaA Phase 3, Randomized, Double-Blind, Multicenter Study Comparing Oral MLN9708 Plus Lenalidomide and Dexamethasone Versus Placebo Plus Lenalidomide and Dexamethasone in Adult Patients With Newly Diagnosed Multiple Myelomahttp://www.clinicaltrials.gov/ct2/show/NCT01850524?term=NCT01850524&rank=1

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