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Kuru

Definition

Kuru is a disease of the nervous system.

Alternative Names

Causes, incidence, and risk factors

Kuru is an extremely rare disease. It is caused by an infectious protein (prion) found in contaminated human brain tissue.

Kuru is found almost exclusively among people from New Guinea, who practiced a form of cannibalism in which the brains of dead people were eaten as part of a funeral ritual.

Kuru causes neurodegenerative changes similar to Creutzfeldt-Jakob disease. Similar diseases appear in cows as bovine spongiform encephalopathy (BSE), also called mad cow disease.

The main risk factor for kuru is eating human brain tissue, which can contain the infectious particles.

Symptoms

Symptoms of kuru include:

  • Coordination problems, eventually becoming severe
  • Difficulty walking (cerebellar ataxia)
  • Swallowing difficulty
  • Tremors and muscle jerks (myoclonus)

Difficulty swallowing and the inability to feed oneself lead to malnutrition or starvation.

It can take up to 30 years or even longer to develop symptoms (incubation period).

Signs and tests

A neurological exam may show changes in coordination and walking ability.

Treatment

There is no known treatment for kuru.

Support Groups

Expectations (prognosis)

Death usually occurs within 1 year after the first sign of symptoms.

Complications

Calling your health care provider

Call your health care provider if you have any walking, swallowing, or coordination problems. Kuru is extremely rare. Your doctor will rule out other neurological diseases.

Prevention

References

Zeidler M. Prion diseases. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007: chap 442.
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    Review Date: 12/3/2008

    Review By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; Jatin M. Vyas, MD, PhD, Assistant Professor in Medicine, Harvard Medical School, Assistant in Medicine, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

    The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- 2010 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

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