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This article may contain information on medical procedures that are not recommended or endorsed by Catholic Health Partners. Promotion of this topic is prohibited by the Ethical and Religious Directives for Catholic Health Services. In the Ethical and Religious Directives, Catholic health institutions are prohibited from condoning contraceptive practices. Married couples should be given information about natural family planning as well as the church’s teachings on responsible parenthood. The information in this article is designed for educational purposes only. It is not provided as a professional service or as medical advice for specific patients.

Bilirubin - blood

Definition

Bilirubin is a yellowish pigment found in bile, a fluid produced by the liver.

This article discusses the laboratory test done to measure bilirubin in the blood. Total and direct bilirubin are usually measured to screen for or to monitor liver or gallbladder problems. Large amounts of bilirubin in the body can lead to jaundice.

A test may also be done to measure bilirubin in a urine sample. For information on that test, see: Bilirubin - urine.

Alternative Names

Total bilirubin - blood; Unconjugated bilirubin - blood; Indirect bilirubin - blood; Conjugated bilirubin - blood; Direct bilirubin - blood

How the test is performed

A blood sample is needed. For information on how this is done, see: Venipuncture .

The laboratory specialist spins the blood in a machine called a centrifuge, which separates the liquid part of the blood (serum) from the cells. The bilirubin test is done on the serum.

How to prepare for the test

You should not eat or drink for at least 4 hours before the test. Your health care provider may instruct you to stop taking drugs that affect the test.

Drugs that can increase bilirubin measurements include allopurinol, anabolic steroids, some antibiotics, antimalaria medications, azathioprine, chlorpropamide, cholinergics, codeine, diuretics, epinephrine, meperidine, methotrexate, methyldopa, MAO inhibitors, morphine, nicotinic acid, birth control pills, phenothiazines, quinidine, rifampin, steroids, sulfonamides, and theophylline.

Drugs that can decrease bilirubin measurements include barbiturates, caffeine, penicillin, and high-dose salicylates such as aspirin.

How the test will feel

Why the test is performed

This test is useful in determining if a patient has liver disease or a blocked bile duct.

Bilirubin metabolism begins with the breakdown of red blood cells in many parts of the body. Red blood cells contain hemoglobin, which is broken down to heme and globin. Heme is converted to bilirubin, which is then carried by albumin in the blood to the liver.

In the liver, most of the bilirubin is chemically attached to another molecule before it is released in the bile. This "conjugated" (attached) bilirubin is called direct bilirubin; unconjugated bilirubin is called indirect bilirubin. Total serum bilirubin equals direct bilirubin plus indirect bilirubin.

Conjugated bilirubin is released into the bile by the liver and stored in the gallbladder, or transferred directly to the small intestines. Bilirubin is further broken down by bacteria in the intestines, and those breakdown products contribute to the color of the feces. A small percentage of these breakdown compounds are taken in again by the body, and eventually appear in the urine.

Normal Values

  • Direct bilirubin: 0 to 0.3 mg/dL
  • Total bilirubin: 0.3 to 1.9 mg/dL

Note: mg/dL = milligrams per deciliter

Normal values may vary slightly from laboratory to laboratory.

What abnormal results mean

Jaundice is a yellowing of the skin and the white part of the eye, which occurs when bilirubin builds up in the blood at a level greater than approximately 2.5 mg/dL. Jaundice occurs because red blood cells are being broken down too fast for the liver to process. This might happen due to liver disease or bile duct blockage.

If the bile ducts are blocked, direct bilirubin will build up, escape from the liver, and end up in the blood. If the levels are high enough, some of it will appear in the urine. Only direct bilirubin appears in the urine. Increased direct bilirubin usually means that the biliary (liver secretion) ducts are obstructed.

Increased indirect or total bilirubin may be a sign of:

Increased direct bilirubin may indicate:

Additional conditions under which the test may be performed:

What the risks are

Special considerations

Factors that interfere with bilirubin testing are:

  • Hemolysis (breakdown) of blood will falsely increase bilirubin levels
  • Lipids in the blood will falsely decrease bilirubin levels
  • Bilirubin is light-sensitive; it breaks down in light

References

Berk PD, Korenblat KM. Approach to the patient with jaundice or abnormal liver test results. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 150.

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Review Date: 2/23/2009

Review By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- 2010 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

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